A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human
نویسندگان
چکیده
R. M. Salek,* M. L. Maguire,* E. Bentley, D. V. Rubtsov, T. Hough, M. Cheeseman, D. Nunez, B. C. Sweatman, J. N. Haselden, R. D. Cox, S. C. Connor, and J. L. Griffin Department of Biochemistry, University of Cambridge, Cambridge; Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire; The Mary Lyon Centre, MRC Harwell, Harwell, Oxfordshire; and Safety Assessment, GlaxoSmithKline, Ware, Herts, United Kingdom
منابع مشابه
Origanum Majoranum Extract Modulates Gene Expression, Hepatic and Renal Changes in a Rat Model of Type 2 Diabetes
The present study was conducted to test the effect of Origanum Majoranum Extract (OME) of leaves on alterations induced in a model of type 2 diabetic rats. Adult male Wistar rats were fed high fat diet for 3 weeks and injected a single dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetic rats. Diabetic rats were given aqueous extract of OME in a dose of 20 mg/kg orally ...
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In this article, we review animal models of types 1 and 2 diabetes mellitus. Models of type 1 diabetes are discussed in two parts, genetic and chemical. Models of type 2 diabetes are discussed in four parts – rat and mouse models, dietary induction, and selective breeding. Models are assessed regarding metabolic disturbances, the condition of the pancreas, long-term complications, and research ...
متن کاملOriganum Majoranum Extract Modulates Gene Expression, Hepatic and Renal Changes in a Rat Model of Type 2 Diabetes
The present study was conducted to test the effect of Origanum Majoranum Extract (OME) of leaves on alterations induced in a model of type 2 diabetic rats. Adult male Wistar rats were fed high fat diet for 3 weeks and injected a single dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetic rats. Diabetic rats were given aqueous extract of OME in a dose of 20 mg/kg orally ...
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